Ivermectin may significantly improve Global Health in MANY ways
Although my focus is currently on how Ivermectin works in combatting COVID-19. I wanted to start a post where I can keep notes on other research I find along the way. Although Ivermectin is proving amazing to combat COVID-19, and is a well-known as an antiparasitic drug, additional uses for Ivermectin and other Avermectin derivatives continue to be found. I’ll update this post as I find things but will most likely focus more on it after I’ve finished all my more-time-critical COVID-19 posts.
Ivermectin is a drug for the world’s poor
IVM is no longer patented (any chemist can make it, so it’s cheap as chips) and already more than 250 million people take it annually to combat pathogens and it’s widespread in some of the poorest countries as an antimalarial, river blindness treatment, and used for scabies and lice, as well as being a common animal antiparasitic. (01)
It’s readily-accessible over-the-counter in some countries, it’s cheap to make, and its long-term safety profile is already well researched and documented.
Ivermectin has shown promise in many other area health areas:
IVM may also significantly improve global health in MANY other areas:
Ivermectin is not only effective as an antiparasitic and against COVID-19, it’s also shown promise in many others areas including as an antibacterial, antiviral, anti-inflammatory, and anticancer agent: (02) (03) (04) (05)
Antibacterial (tuberculosis, Buruli ulcer)
Antiviral (HIV, dengue, encephalitis)
RNA Viruses (Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, severe acute respiratory syndrome coronavirus 2)
DNA Viruses (Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, bovine herpesvirus 1)
Anticancer (breast cancer, leukemia, glioblastoma, cervical cancer, gastric cancer, ovarian cancer, colon cancer, melanoma, pancreatic cancer, lung cancer, thyroid cancer, cholangiocarcinoma/bile duct cancer), and Antitumor (hepatoma, glioma, myeloma, neurofibromatosis tumors) (06) (07) (08) (09) (10) (11) (12) (13)
Neurological diseases (prevention of alcohol disorders, motor neurone disease, amyotrophic lateral sclerosis)
Metabolic related diseases (hyperglycemia, insulin resistance, hypertriglyceridemia, hypercholesterolemia, diabetes, obesity, etc.)
Famesoid X receptor-mediated diseases (cholestasia, gallstones, non-alcohol fatty liver disease, atherosclerosis, inflammation, etc.)
Disease fighting potential - Myiasis, Trichinosis, Insects, Malaria, Leishmaniasis, African trypanosomiasis, ticks, schistosomiasis, bedbugs, Rosacea, Asthma, Epilepsy, and more.
I'll focus my attention on this a lot more after the COVID-19 series has completed. If you are interested in the meantime, you can do a search for any of the above on PubMed, Google Scholar, Nature, etc. to look up the latest research yourself.
|01||Over 25 Years of Clinical Experience With Ivermectin: An Overview of Safety for an Increasing Number of Indications|
|02||Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations|
|03||Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen|
|04||A list of studies revealed antiviral effects of ivermectin on RNA and DNA viruses|
|05||Ivermectin: An Anthelmintic, an Insecticide, and Much More|
|06||Tang M, Hu X, Wang Y, et al. Ivermectin, a potential anticancer drug derived from an antiparasitic drug. Pharmacol Res. 2021;163:105207. doi:10.1016/j.phrs.2020.105207|
|07||At the Chinese Academy of Sciences’ Institute of Zoology in Beijing, scientists injected Ivermectin (IVM) into the bodies of mice with solid tumors. The cancer cells, which previously had been highly drug-resistant, immediately threw in the towel. To confirm the types of cancers that might succumb, Professor Wu Yijun and his colleagues then treated human breast cancers cells with IVM and produced the same results. - Jiang, L., Wang, P., Sun, YJ. et al. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway. J Exp Clin Cancer Res 38, 265 (2019). https://doi.org/10.1186/s13046-019-1251-7|
|08||As long ago as 2009, Dr Hisashi Hashimto and his team of scientists showed that Ivermectin could block the PAK1 pathway in resistant ovarian cancers. Hashimoto H, Messerli SM, Sudo T, Maruta H. Ivermectin inactivates the kinase PAK1 and blocks the PAK1-dependent growth of human ovarian cancer and NF2 tumor cell lines. Drug Discov Ther. 2009 Dec;3(6):243-6. PMID: 22495656.|
|09||Schistosoma-Associated Bladder Cancer - Siddiqui AJ, Khan MF, Hamadou WS, et al. Molecular Docking and Dynamics Simulation Revealed Ivermectin as Potential Drug against Schistosoma-Associated Bladder Cancer Targeting Protein Signaling: Computational Drug Repositioning Approach. Medicina (Kaunas). 2021;57(10):1058. Published 2021 Oct 3. doi:10.3390/medicina57101058|
|10||Ovarian Cancer - Li N, Zhan X. Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes. EPMA J. 2020;11(2):289-309. Published 2020 May 28. doi:10.1007/s13167-020-00209-y|
|11||Colorectal Cancer - Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth|
|12||Drug-Resistant Cancer Cells - Jiang L, Wang P, Sun YJ, Wu YJ. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway. J Exp Clin Cancer Res. 2019 Jun 18;38(1):265. doi: 10.1186/s13046-019-1251-7. PMID: 31215501; PMCID: PMC6580523.|
|13||Tumors and induces apoptosis - Tang, Mingyang et al. “Ivermectin, a potential anticancer drug derived from an antiparasitic drug.” Pharmacological research vol. 163 (2021): 105207. doi:10.1016/j.phrs.2020.105207|