Ivermectin may significantly improve Global Health in MANY ways

on June 7, 2021 IN Ivermectin

Updated:2 years ago
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Although my focus is currently on how Ivermectin works in combatting COVID-19. I wanted to start a post where I can keep notes on other research I find along the way. Although Ivermectin is proving amazing to combat COVID-19, and is a well-known as an antiparasitic drug, additional uses for Ivermectin and other Avermectin derivatives continue to be found. I’ll update this post as I find things but will most likely focus more on it after I’ve finished all my more-time-critical COVID-19 posts.

Ivermectin is a drug for the world’s poor

IVM is no longer patented (any chemist can make it, so it’s cheap as chips) and already more than 250 million people take it annually to combat pathogens and it’s widespread in some of the poorest countries as an antimalarial, river blindness treatment, and used for scabies and lice, as well as being a common animal antiparasitic. ⁽⁰¹⁾Over 25 Years of Clinical Experience With Ivermectin: An Overview of Safety for an Increasing Number of Indications

It’s readily-accessible over-the-counter in some countries, it’s cheap to make, and its long-term safety profile is already well researched and documented.

Ivermectin has shown promise in many other area health areas:

IVM may also significantly improve global health in MANY other areas:
Ivermectin is not only effective as an antiparasitic and against COVID-19, it’s also shown promise in many others areas including as an antibacterial, antiviral, anti-inflammatory, and anticancer agent: ⁽⁰²⁾Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations ⁽⁰³⁾Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen ⁽⁰⁴⁾A list of studies revealed antiviral effects of ivermectin on RNA and DNA viruses ⁽⁰⁵⁾Ivermectin: An Anthelmintic, an Insecticide, and Much More

Antibacterial (tuberculosis, Buruli ulcer)

Antiviral (HIV, dengue, encephalitis)

RNA Viruses (Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki Forest, Sindbis, Avian influenza A, Porcine Reproductive and Respiratory Syndrome, Human immunodeficiency virus type 1, severe acute respiratory syndrome coronavirus 2)

DNA Viruses (Equine herpes type 1, BK polyomavirus, pseudorabies, porcine circovirus 2, bovine herpesvirus 1)

Anticancer (breast cancer, leukemia, glioblastoma, cervical cancer, gastric cancer, ovarian cancer, colon cancer, melanoma, pancreatic cancer, lung cancer, thyroid cancer, cholangiocarcinoma/bile duct cancer), and Antitumor (hepatoma, glioma, myeloma, neurofibromatosis tumors) ⁽⁰⁶⁾Tang M, Hu X, Wang Y, et al. Ivermectin, a potential anticancer drug derived from an antiparasitic drug. Pharmacol Res. 2021;163:105207. doi:10.1016/j.phrs.2020.105207 ⁽⁰⁷⁾At the Chinese Academy of Sciences’ Institute of Zoology in Beijing, scientists injected Ivermectin (IVM) into the bodies of mice with solid tumors. The cancer cells, which previously had been highly drug-resistant, immediately threw in the … Click for full citation ⁽⁰⁸⁾As long ago as 2009, Dr Hisashi Hashimto and his team of scientists showed that Ivermectin could block the PAK1 pathway in resistant ovarian cancers. Hashimoto H, Messerli SM, Sudo T, Maruta H. Ivermectin inactivates the kinase PAK1 and blocks the … Click for full citation ⁽⁰⁹⁾Schistosoma-Associated Bladder Cancer - Siddiqui AJ, Khan MF, Hamadou WS, et al. Molecular Docking and Dynamics Simulation Revealed Ivermectin as Potential Drug against Schistosoma-Associated Bladder Cancer Targeting Protein Signaling: … Click for full citation ⁽¹⁰⁾Ovarian Cancer - Li N, Zhan X. Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes. EPMA J. 2020;11(2):289-309. Published 2020 May 28. doi:10.1007/s13167-020-00209-y ⁽¹¹⁾Colorectal Cancer - Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth ⁽¹²⁾Drug-Resistant Cancer Cells - Jiang L, Wang P, Sun YJ, Wu YJ. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway. J Exp Clin Cancer Res. 2019 Jun 18;38(1):265. doi: 10.1186/s13046-019-1251-7. PMID: 31215501; … Click for full citation ⁽¹³⁾Tumors and induces apoptosis - Tang, Mingyang et al. “Ivermectin, a potential anticancer drug derived from an antiparasitic drug.” Pharmacological research vol. 163 (2021): 105207. doi:10.1016/j.phrs.2020.105207

Neurological diseases (prevention of alcohol disorders, motor neurone disease, amyotrophic lateral sclerosis)

Metabolic related diseases (hyperglycemia, insulin resistance, hypertriglyceridemia, hypercholesterolemia, diabetes, obesity, etc.)

Famesoid X receptor-mediated diseases (cholestasia, gallstones, non-alcohol fatty liver disease, atherosclerosis, inflammation, etc.)

Disease fighting potential - Myiasis, Trichinosis, Insects, Malaria, Leishmaniasis, African trypanosomiasis, ticks, schistosomiasis, bedbugs, Rosacea, Asthma, Epilepsy, and more.

I'll focus my attention on this a lot more after the COVID-19 series has completed. If you are interested in the meantime, you can do a search for any of the above on PubMed, Google Scholar, Nature, etc. to look up the latest research yourself.

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References[+]

References
01	Over 25 Years of Clinical Experience With Ivermectin: An Overview of Safety for an Increasing Number of Indications
02	Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations
03	Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen
04	A list of studies revealed antiviral effects of ivermectin on RNA and DNA viruses
05	Ivermectin: An Anthelmintic, an Insecticide, and Much More
06	Tang M, Hu X, Wang Y, et al. Ivermectin, a potential anticancer drug derived from an antiparasitic drug. Pharmacol Res. 2021;163:105207. doi:10.1016/j.phrs.2020.105207
07	At the Chinese Academy of Sciences’ Institute of Zoology in Beijing, scientists injected Ivermectin (IVM) into the bodies of mice with solid tumors. The cancer cells, which previously had been highly drug-resistant, immediately threw in the towel. To confirm the types of cancers that might succumb, Professor Wu Yijun and his colleagues then treated human breast cancers cells with IVM and produced the same results. - Jiang, L., Wang, P., Sun, YJ. et al. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway. J Exp Clin Cancer Res 38, 265 (2019). https://doi.org/10.1186/s13046-019-1251-7
08	As long ago as 2009, Dr Hisashi Hashimto and his team of scientists showed that Ivermectin could block the PAK1 pathway in resistant ovarian cancers. Hashimoto H, Messerli SM, Sudo T, Maruta H. Ivermectin inactivates the kinase PAK1 and blocks the PAK1-dependent growth of human ovarian cancer and NF2 tumor cell lines. Drug Discov Ther. 2009 Dec;3(6):243-6. PMID: 22495656.
09	Schistosoma-Associated Bladder Cancer - Siddiqui AJ, Khan MF, Hamadou WS, et al. Molecular Docking and Dynamics Simulation Revealed Ivermectin as Potential Drug against Schistosoma-Associated Bladder Cancer Targeting Protein Signaling: Computational Drug Repositioning Approach. Medicina (Kaunas). 2021;57(10):1058. Published 2021 Oct 3. doi:10.3390/medicina57101058
10	Ovarian Cancer - Li N, Zhan X. Anti-parasite drug ivermectin can suppress ovarian cancer by regulating lncRNA-EIF4A3-mRNA axes. EPMA J. 2020;11(2):289-309. Published 2020 May 28. doi:10.1007/s13167-020-00209-y
11	Colorectal Cancer - Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth
12	Drug-Resistant Cancer Cells - Jiang L, Wang P, Sun YJ, Wu YJ. Ivermectin reverses the drug resistance in cancer cells through EGFR/ERK/Akt/NF-κB pathway. J Exp Clin Cancer Res. 2019 Jun 18;38(1):265. doi: 10.1186/s13046-019-1251-7. PMID: 31215501; PMCID: PMC6580523.
13	Tumors and induces apoptosis - Tang, Mingyang et al. “Ivermectin, a potential anticancer drug derived from an antiparasitic drug.” Pharmacological research vol. 163 (2021): 105207. doi:10.1016/j.phrs.2020.105207

Penny... on Health

Truth-seeker, ever-questioning, ever-learning, ever-researching, ever delving further and deeper, ever trying to 'figure it out'. This site is a legacy of sorts, a place to collect thoughts, notes, book summaries, & random points of interests.

DISCLAIMER: The information on this website is not medical science or medical advice. I do not have any medical training aside from my own research and interest in this area. The information I publish is not intended to diagnose, treat, cure or prevent any disease, disorder, pain, injury, deformity, or physical or mental condition. I just report my own results, understanding & research.

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