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Polyvinylpyrrolidone (PVP) in its pure form is considered safe & even edible by humans, however it doesn’t have any health “benefits” & usually just passes through the body. There have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes.