Spike Protein Goes to Nucleus and Impairs DNA Repair

on November 15, 2021 IN JABS

Updated:1 year ago
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New study shows the spike protein impairs DNA repair which is a serious concern for COVID-19 mRNA vaccines that focus on the spike protein.

Post started: 5th November, 2021. Last Updated: 15th November, 2021

In this concerning in-vitro study the researchers show how SARS-COV-2 Spike protein and other proteins go to a cell’s nucleus and impair DNA repair and cell’s immune responses.

This study ^{⁽⁰¹⁾ SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro – Pubmed}– even though it’s in-vitro (and we will be 180 years old before anyone questions the vaccines enough to follow-up on actual human studies since everyone is in a “safe & effective” trance and ignores any ‘science’ or ‘injuries’ that casts any doubts on these experimental biologicals – is yet another possible explanation on why people are getting really serious injuries post-jab. ^{⁽⁰²⁾ [Rant] I’m heartbroken and helpless and concerned and need to share ⁽⁰³⁾ C-19 Vaccines [Videos] Doctors & Nurses ⁽⁰⁴⁾ Aussie Health Workers On Jab Policies ⁽⁰⁵⁾ Verifiable References For Aussies ⁽⁰⁶⁾ COVID Vaccine Victims Silenced ⁽⁰⁷⁾ Against Our Will ⁽⁰⁸⁾ Against Our Will [Europe]}

https://www.mdpi.com/1999-4915/13/10/2056 ⁽⁰⁹⁾Jiang, H.; Mei, Y.-F. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. *Viruses* **2021**, 13, 2056. https://doi.org/10.3390/v13102056

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS-CoV-2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID-19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS-CoV-2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS-CoV-2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.

Abstract

Dr Been – Double Vaccinated – explains in depth in an easy-to-understand way what the study found and I highly recommend ANYONE – even those who don’t intend to get the jab – to watch it, download the study, and understand it. It may help save a life of someone you know or meet.

YouTube ^{⁽¹⁰⁾ DrBeen – Spike Protein Goes to Nucleus and Impairs DNA Repair (In-Vitro Study) – YouTube} | Odysee ^{⁽¹¹⁾ DrBeen -Spike Protein Goes to Nucleus and Impairs DNA Repair (In-Vitro Study) – Odysee}

This is a scary publication, made even more scary in that it reminds me of some of the earlier material I’ve got in my research collection and how it may all be connected to those who are now getting aggressive onset cancer and other serious injuries ^{⁽¹²⁾ Covid Vaccine Injuries} within weeks of taking the jab, and I don’t know if I’m over-thinking but it’s the first thing I thought of and I want to look into it more.

Some doctors are reporting that their patients who were in remission for years are suddenly having cancers spread throughout their entire body within weeks of the jab, ^{⁽¹³⁾ An unmentioned side-effect of Covid vaccines? https://www.canceractive.com/article/an-unmentioned%20sideeffect%20of%20covid%20vaccines} and I’ve seen reports of people who died of a brain tumor or had a sudden onset aggressive cancer that they never knew they had – despite the “pharma-funded fact-checkers” ^{⁽¹⁴⁾ Pharma-Funded Fact-Checkers}, “pharma-funded cancer charities”^{⁽¹⁵⁾ Lies And Damn Lies About Breast Cancer Awareness And Cancer Charities – cancerwisdom.net}, “pharma-funded media” ^{⁽¹⁶⁾ Rigged-Media}, and “Pharma-Funded Health Authorities” ^{⁽¹⁷⁾ Rigged-Agenda ⁽¹⁸⁾ She quit Big Pharma to help cancer patients heal naturally https://www.chrisbeatcancer.com/she-quit-big-pharma-to-help-cancer-patients-heal-naturally/} saying there is no link. Sorry but I tend to believe those who are “censored” now with everything to lose rather than those who are being paid a fortune to keep the “jab in all arms”, “ignore the victims” and “dismiss any science ^{⁽¹⁹⁾ Rigged-Science} that doesn’t fit their agenda” ^{⁽²⁰⁾ Rigged-Agenda} campaign. ^{⁽²¹⁾ Covid Vaccines and Cancer – Swiss Policy Research}. Clinical pathologist Dr. Ryan Cole described a significant increase in certain types of cancer (e.g. endometrial cancer) since the beginning of the covid mass vaccination campaign. ^{⁽²²⁾ Clinical pathologist Dr. Ryan Cole described a significant increase in certain types of cancer (e.g. endometrial cancer) since the beginning of the covid mass vaccination campaign} and German pathologists also noted the issue of post-vaccination immune dysregulation and sudden tumor growth in some patients. ^{⁽²³⁾ CAUSE OF DEATH AFTER COVID-19 VACCINATION Press Conference – German pathologists}

I recall coming across a patent that is eerily familiar – it was a controversial patent regarding the detection of two ‘cancer-modulating’ genes BRCA1 and BRCA2 ^{⁽²⁴⁾ https://www.supremecourt.gov/opinions/12pdf/12-398_1b7d.pdf – it looks like they have deleted the file, lucky I’m a geek, I’ve got my highlighted version and the original in my Mega folder here: https://mega.nz/fm/rjxyCYra} – something along the lines of when those have been mutated in some way, they dramatically increase the risk of breast and ovarian cancer. The reason it was controversial was something to do with patenting human genes and naturally-occurring associations between genes and diseases, and at the time I think it was rejected but now the world has shifted to some kind of evil and that may of been overturned in 2019 as I saw a letter from one of the labs trying to stop a particular amendment to Section 101 of the Patent Act which would change legislation in regards to patenting products & laws of nature, to which they referred to the previously denied patent as a major concern as to why they opposed the amendment.^{⁽²⁵⁾ https://www.amp.org/Section101SignOnLetter}

I have too many things open right now to dig deeper, and there is so many important things I’m trying to get uploaded that people aren’t aware of due to the evil censorship, ⁽²⁶⁾ Rigged-Media so I won’t try and find all the material right now but I will endeavour to look into it when I have more time and if there is some connection. If you are keen to look into it rather than wait for me, it will be amongst my uploaded research (I’d already started doing a little background research on it at the time and highlighted the important points in the documents before moving onto something else. (Search for Patent – DNA)

Dr Mikolaj Raszek – Same study – from the point of view from Genetics researcher.

Dr. Mikolaj Raszek – Spike protein inside nucleus enhancing DNA damage? – COVID-19 mRNA vaccines – YouTube ^{⁽²⁷⁾ Dr. Mikolaj Raszek – Spike protein inside nucleus enhancing DNA damage? – COVID-19 mRNA vaccines – YouTube}

Dr. Mikolaj Raszek Credentials: https://merogenomics.ca/en/about/ ^{⁽²⁸⁾ Dr. Mikolaj Raszek Credentials: https://merogenomics.ca/en/about/}

This video discusses new surprise discovery (yet to be confirmed by other scientists) that SARS-CoV-2 full length spike protein can enter human cell nuclei and interfere with fixing of broken DNA damage. Authors of the study propose this might have been evolved in order to prevent genetic recombination required to produce antibody variety to successfully attack the virus. If true, and if this could have important implications for potential negative health outcomes and might require reconfiguration of vaccine design.

00:00 Dr Mikolaj Raszek, Phd from Merogenomics
00:09 The latest widest news in Molecular Microbiology
00:33 WHO? Swedish research shows spike protein enters nucleus in human cells (in vitro)
00:57 this is of course, biologically verboten (*German for STRICTLY FORBIDDEN)
01:04 WHAT? *Discovery* Spike protein inhibits proper fixing of broken DNA
01:18 Specifics: double stranded breaks where both strands are broken
01:33 HOW? Mechanism 1 suspected interference with BRCA1 gene product’s ability to repair DNA
01:48 Consequence: if BRCA1 is mutated though, then you have highest predisposition for Cancer development precisely because BRCA1 gene codes for proteins that fix DNA damage when sheared in half
02:14 Significance: Consequences are so great if true that it should be double checked, verified and reinvestigated
2:42 Call for a lot more studies: Revalidation
2:51 HOW? Mechanism 2 Spike also interferes with mysterious nuclear protein 53BP1 which may serve to prevent DNA breaks from re-ligating to other DNA sources ensuring 2 chromosomes don’t link together that aren’t supposed to.
4:21 HOW? Mechanism 3 Perhaps spike in Nuclei interferes with Immune cells’ mechanisms (eg.BRCA1 and 53BP1) and diversity of response to infections.
4:42 TAKEAWAY What if Spike protein evolved as a mutagen for DNA – what would implications be for a vaccine that’s primary focus was to produce Spike?
5:32 CONTEXT: Recent discovery that Spikes may circulate for months on end in Exosomes to different parts of the body and in theory enter cells well after the point of vaccination as COVID-19 mRNA vaccines update 16 discussed
06:15 CONTEXT: DNA gets 70k lesions/day /cell! But only 25 are double stranded shearing damages. Very, very important that we do not dismiss this study.
07:25 IMPLICATIONS: So within this context, what are the chances circulating spike proteins could enter and damage DNA and predispose to cancer? In cancer, it takes months for damage to accumulate and cause symptoms. Therefore…
7:45 IMPLICATION: Vaccine Safety Are vaccines “SAFE”? What is vaccine “Safety”? Only Time can/will tell.
8:07 IMPLICATION: Yes, Vaccines don’t produce dangerous clinical symptoms in the first few months BUT we don’t know what they do in very long-term basis so can we call them safe?
8:34 HOW? Mechanism 4 Vaccines use FULL length of spike protein thus produces whole protein in body. Prior to vaccinations some scientists mentioned that FULL protein length of Spike protein was dangerous
9:16 IMPLICATION: Antibody Dependent Enhancement ^{⁽²⁹⁾ Informed Consent Should Include This Warning Prominently & Individually Explained (ADE)} or ADE could occur with use of full length of Spike protein
10:27: AUTHORS’ RECOMMENDATION: Not to use full length of spike protein but only the Receptor Binding Domain or RBD portion for vaccines
10:41 Explanation: RBD
11:29: TAKE AWAY Vaccine Safety This shows how Vaccines are still uncharacterized on what they might be doing at the molecular level once injected in us.
11:52 Spike protein also uncharacterized post-infection (but learning lots now).

Related Research to understanding study:

SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro ^{⁽³⁰⁾ Jiang H, Mei Y-F. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses. 2021; 13(10):2056. https://doi.org/10.3390/v13102056}
BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation^{⁽³¹⁾BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation, Cell Reports, Volume 18, Issue 2, 2017, Pages 520-532, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2016.12.042. Mayu Isono, Atsuko Niimi, … Click for full citation}
V(D)J recombination ^{⁽³²⁾V(D)J recombination is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. It results in the highly diverse repertoire … Click for full citation}
A simplified model for NHEJ and HR. When a DNA double-strand break (DSB) occurs during G1, it is repaired via NHEJ (IMAGES from Publication) ^{⁽³³⁾ A simplified model for NHEJ and HR. When a DNA double-strand break (DSB) occurs during G1, it is repaired via NHEJ (IMAGES from Publication)}
The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells ^{⁽³⁴⁾De Lorenzo, Silvana & Patel, Anand & Hurley, Rachel & Kaufmann, Scott. (2013). The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells. Frontiers in oncology. 3. 228. … Click for full citation}
Other Interesting studies regarding writing foreign RNA into the genetic DNA code^{⁽³⁵⁾ Scientists Find Cancer Drivers Hiding in a New Place ⁽³⁶⁾Human cells can write foreign RNA into genetic DNA code ⁽³⁷⁾ Polθ reverse transcribes RNA and promotes RNA-templated DNA repair – Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. — Xiaojiang S. Chen,Richard T. Pomerantz}

Is Spike Protein Causing Catastrophic Damage To DNA? Video & Animation explainer

Bitchute Jeffery Jaxen, Investigative Journalist & Del BigTree, TheHighWire.com, Nov 15th, 2021

Explains another Swedish study which highlights the danger that the injection could block an action that repairs your DNA on a constant basis, then that could increase cancer-formation and other autoimmune issues. This video is explaining two different studies – the one above, and the other on 53BP1). ^{⁽³⁸⁾Mirza-Aghazadeh-Attari M, Mohammadzadeh A, Yousefi B, Mihanfar A, Karimian A, Majidinia M. 53BP1: A key player of DNA damage response with critical functions in cancer. DNA Repair (Amst). 2019 Jan;73:110-119. doi: 10.1016/j.dnarep.2018.11.008. Epub … Click for full citation}

These studies show that the spike protein impairs the DNA repair mechanism by about 80% in 2 different pathways (NHEJ & HR via inhibiting both he BRCA1 and 53BP1 genes). Jaxen says he was told that 53BP1 is called “The Guardian of the Genome” – it has been extensively demonstrated that aberrant expression of 53BP1 contributes to tumor occurrence and development. 53BP1 loss of function in tumor tissues is also related to tumor progression and poor prognosis in human malignancies.

Jaxan says that he checked the FDA package insert to see if the vaccines were tested for this, and found that Pfizer, Moderna, and J&J said the same thing. ^{⁽³⁹⁾ FDA Package Insert – Comrinaty (purple cap)}

https://www.fda.gov/media/151707/download

References:

SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro ^{⁽⁴⁰⁾ Jiang H, Mei YF. SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses. 2021 Oct 13;13(10):2056. doi: 10.3390/v13102056. PMID: 34696485; PMCID: PMC8538446.}
53BP1: A key player of DNA damage response with critical functions in cancer ^{⁽⁴¹⁾Mirza-Aghazadeh-Attari M, Mohammadzadeh A, Yousefi B, Mihanfar A, Karimian A, Majidinia M. 53BP1: A key player of DNA damage response with critical functions in cancer. DNA Repair (Amst). 2019 Jan;73:110-119. doi: 10.1016/j.dnarep.2018.11.008. Epub … Click for full citation}
FDA Package Insert – Comrinaty (purple cap) ^{⁽⁴²⁾ FDA Package Insert – Comrinaty (purple cap)}

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References[+]

References
01	SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro – Pubmed
02	[Rant] I’m heartbroken and helpless and concerned and need to share
03	C-19 Vaccines [Videos] Doctors & Nurses
04	Aussie Health Workers On Jab Policies
05	Verifiable References For Aussies
06	COVID Vaccine Victims Silenced
07	Against Our Will
08	Against Our Will [Europe]
09	Jiang, H.; Mei, Y.-F. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses 2021, 13, 2056. https://doi.org/10.3390/v13102056
10	DrBeen – Spike Protein Goes to Nucleus and Impairs DNA Repair (In-Vitro Study) – YouTube
11	DrBeen -Spike Protein Goes to Nucleus and Impairs DNA Repair (In-Vitro Study) – Odysee
12	Covid Vaccine Injuries
13	An unmentioned side-effect of Covid vaccines? https://www.canceractive.com/article/an-unmentioned%20sideeffect%20of%20covid%20vaccines
14	Pharma-Funded Fact-Checkers
15	Lies And Damn Lies About Breast Cancer Awareness And Cancer Charities – cancerwisdom.net
16	Rigged-Media
17	Rigged-Agenda
18	She quit Big Pharma to help cancer patients heal naturally https://www.chrisbeatcancer.com/she-quit-big-pharma-to-help-cancer-patients-heal-naturally/
19	Rigged-Science
20	Rigged-Agenda
21	Covid Vaccines and Cancer – Swiss Policy Research
22	Clinical pathologist Dr. Ryan Cole described a significant increase in certain types of cancer (e.g. endometrial cancer) since the beginning of the covid mass vaccination campaign
23	CAUSE OF DEATH AFTER COVID-19 VACCINATION Press Conference – German pathologists
24	https://www.supremecourt.gov/opinions/12pdf/12-398_1b7d.pdf – it looks like they have deleted the file, lucky I’m a geek, I’ve got my highlighted version and the original in my Mega folder here: https://mega.nz/fm/rjxyCYra
25	https://www.amp.org/Section101SignOnLetter
26	Rigged-Media
27	Dr. Mikolaj Raszek – Spike protein inside nucleus enhancing DNA damage? – COVID-19 mRNA vaccines – YouTube
28	Dr. Mikolaj Raszek Credentials: https://merogenomics.ca/en/about/
29	Informed Consent Should Include This Warning Prominently & Individually Explained (ADE)
30	Jiang H, Mei Y-F. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses. 2021; 13(10):2056. https://doi.org/10.3390/v13102056
31	BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation, Cell Reports, Volume 18, Issue 2, 2017, Pages 520-532, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2016.12.042. Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano, Atsushi Shibata
32	V(D)J recombination is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. It results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors (TCRs) found in B cells and T cells, respectively. The process is a defining feature of the adaptive immune system. V(D)J recombination in mammals occurs in the primary lymphoid organs (bone marrow for B cells and thymus for T cells) and in a nearly random fashion rearranges variable (V), joining (J), and in some cases, diversity (D) gene segments. The process ultimately results in novel amino acid sequences in the antigen-binding regions of immunoglobulins and TCRs that allow for the recognition of antigens from nearly all pathogens including bacteria, viruses, parasites, and worms as well as “altered self cells” as seen in cancer. The recognition can also be allergic in nature (e.g. to pollen or other allergens) or may match host tissues and lead to autoimmunity.
33	A simplified model for NHEJ and HR. When a DNA double-strand break (DSB) occurs during G1, it is repaired via NHEJ (IMAGES from Publication)
34	De Lorenzo, Silvana & Patel, Anand & Hurley, Rachel & Kaufmann, Scott. (2013). The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells. Frontiers in oncology. 3. 228. 10.3389/fonc.2013.00228.
35	Scientists Find Cancer Drivers Hiding in a New Place
36	Human cells can write foreign RNA into genetic DNA code
37	Polθ reverse transcribes RNA and promotes RNA-templated DNA repair – Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. — Xiaojiang S. Chen,Richard T. Pomerantz
38	Mirza-Aghazadeh-Attari M, Mohammadzadeh A, Yousefi B, Mihanfar A, Karimian A, Majidinia M. 53BP1: A key player of DNA damage response with critical functions in cancer. DNA Repair (Amst). 2019 Jan;73:110-119. doi: 10.1016/j.dnarep.2018.11.008. Epub 2018 Nov 20. PMID: 30497961.
39, 42	FDA Package Insert – Comrinaty (purple cap)
40	Jiang H, Mei YF. SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses. 2021 Oct 13;13(10):2056. doi: 10.3390/v13102056. PMID: 34696485; PMCID: PMC8538446.
41	Mirza-Aghazadeh-Attari M, Mohammadzadeh A, Yousefi B, Mihanfar A, Karimian A, Majidinia M. 53BP1: A key player of DNA damage response with critical functions in cancer. DNA Repair (Amst). 2019 Jan;73:110-119. doi: 10.1016/j.dnarep.2018.11.008. Epub 2018 Nov 20. PMID: 30497961.

Penny... on Health

Truth-seeker, ever-questioning, ever-learning, ever-researching, ever delving further and deeper, ever trying to 'figure it out'. This site is a legacy of sorts, a place to collect thoughts, notes, book summaries, & random points of interests.

DISCLAIMER: The information on this website is not medical science or medical advice. I do not have any medical training aside from my own research and interest in this area. The information I publish is not intended to diagnose, treat, cure or prevent any disease, disorder, pain, injury, deformity, or physical or mental condition. I just report my own results, understanding & research.

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