Spike Protein Goes to Nucleus and Impairs DNA Repair
New study shows the spike protein impairs DNA repair which is a serious concern for COVID-19 mRNA vaccines that focus on the spike protein.
Post started: 5th November, 2021. Last Updated: 15th November, 2021
In this concerning in-vitro study the researchers show how SARS-COV-2 Spike protein and other proteins go to a cell’s nucleus and impair DNA repair and cell’s immune responses.
This study (01) – even though it’s in-vitro (and we will be 180 years old before anyone questions the vaccines enough to follow-up on actual human studies since everyone is in a “safe & effective” trance and ignores any ‘science’ or ‘injuries’ that casts any doubts on these experimental biologicals – is yet another possible explanation on why people are getting really serious injuries post-jab. (02) (03) (04) (05) (06) (07) (08)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS-CoV-2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID-19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS-CoV-2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS-CoV-2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity. Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.
Dr Been – Double Vaccinated – explains in depth in an easy-to-understand way what the study found and I highly recommend ANYONE – even those who don’t intend to get the jab – to watch it, download the study, and understand it. It may help save a life of someone you know or meet.
This is a scary publication, made even more scary in that it reminds me of some of the earlier material I’ve got in my research collection and how it may all be connected to those who are now getting aggressive onset cancer and other serious injuries (12) within weeks of taking the jab, and I don’t know if I’m over-thinking but it’s the first thing I thought of and I want to look into it more.
Some doctors are reporting that their patients who were in remission for years are suddenly having cancers spread throughout their entire body within weeks of the jab, (13) and I’ve seen reports of people who died of a brain tumor or had a sudden onset aggressive cancer that they never knew they had – despite the “pharma-funded fact-checkers” (14), “pharma-funded cancer charities” (15), “pharma-funded media” (16), and “Pharma-Funded Health Authorities” (17) (18) saying there is no link. Sorry but I tend to believe those who are “censored” now with everything to lose rather than those who are being paid a fortune to keep the “jab in all arms”, “ignore the victims” and “dismiss any science (19) that doesn’t fit their agenda” (20) campaign. (21). Clinical pathologist Dr. Ryan Cole described a significant increase in certain types of cancer (e.g. endometrial cancer) since the beginning of the covid mass vaccination campaign. (22) and German pathologists also noted the issue of post-vaccination immune dysregulation and sudden tumor growth in some patients. (23)
I recall coming across a patent that is eerily familiar – it was a controversial patent regarding the detection of two ‘cancer-modulating’ genes BRCA1 and BRCA2 (24) – something along the lines of when those have been mutated in some way, they dramatically increase the risk of breast and ovarian cancer. The reason it was controversial was something to do with patenting human genes and naturally-occurring associations between genes and diseases, and at the time I think it was rejected but now the world has shifted to some kind of evil and that may of been overturned in 2019 as I saw a letter from one of the labs trying to stop a particular amendment to Section 101 of the Patent Act which would change legislation in regards to patenting products & laws of nature, to which they referred to the previously denied patent as a major concern as to why they opposed the amendment. (25)
I have too many things open right now to dig deeper, and there is so many important things I’m trying to get uploaded that people aren’t aware of due to the evil censorship, (26) so I won’t try and find all the material right now but I will endeavour to look into it when I have more time and if there is some connection. If you are keen to look into it rather than wait for me, it will be amongst my uploaded research (I’d already started doing a little background research on it at the time and highlighted the important points in the documents before moving onto something else. (Search for Patent – DNA)
Dr Mikolaj Raszek – Same study – from the point of view from Genetics researcher.
This video discusses new surprise discovery (yet to be confirmed by other scientists) that SARS-CoV-2 full length spike protein can enter human cell nuclei and interfere with fixing of broken DNA damage. Authors of the study propose this might have been evolved in order to prevent genetic recombination required to produce antibody variety to successfully attack the virus. If true, and if this could have important implications for potential negative health outcomes and might require reconfiguration of vaccine design.
00:00 Dr Mikolaj Raszek, Phd from Merogenomics
00:09 The latest widest news in Molecular Microbiology
00:33 WHO? Swedish research shows spike protein enters nucleus in human cells (in vitro)
00:57 this is of course, biologically verboten (*German for STRICTLY FORBIDDEN)
01:04 WHAT? *Discovery* Spike protein inhibits proper fixing of broken DNA
01:18 Specifics: double stranded breaks where both strands are broken
01:33 HOW? Mechanism 1 suspected interference with BRCA1 gene product’s ability to repair DNA
01:48 Consequence: if BRCA1 is mutated though, then you have highest predisposition for Cancer development precisely because BRCA1 gene codes for proteins that fix DNA damage when sheared in half
02:14 Significance: Consequences are so great if true that it should be double checked, verified and reinvestigated
2:42 Call for a lot more studies: Revalidation
2:51 HOW? Mechanism 2 Spike also interferes with mysterious nuclear protein 53BP1 which may serve to prevent DNA breaks from re-ligating to other DNA sources ensuring 2 chromosomes don’t link together that aren’t supposed to.
4:21 HOW? Mechanism 3 Perhaps spike in Nuclei interferes with Immune cells’ mechanisms (eg.BRCA1 and 53BP1) and diversity of response to infections.
4:42 TAKEAWAY What if Spike protein evolved as a mutagen for DNA – what would implications be for a vaccine that’s primary focus was to produce Spike?
5:32 CONTEXT: Recent discovery that Spikes may circulate for months on end in Exosomes to different parts of the body and in theory enter cells well after the point of vaccination as COVID-19 mRNA vaccines update 16 discussed
06:15 CONTEXT: DNA gets 70k lesions/day /cell! But only 25 are double stranded shearing damages. Very, very important that we do not dismiss this study.
07:25 IMPLICATIONS: So within this context, what are the chances circulating spike proteins could enter and damage DNA and predispose to cancer? In cancer, it takes months for damage to accumulate and cause symptoms. Therefore…
7:45 IMPLICATION: Vaccine Safety Are vaccines “SAFE”? What is vaccine “Safety”? Only Time can/will tell.
8:07 IMPLICATION: Yes, Vaccines don’t produce dangerous clinical symptoms in the first few months BUT we don’t know what they do in very long-term basis so can we call them safe?
8:34 HOW? Mechanism 4 Vaccines use FULL length of spike protein thus produces whole protein in body. Prior to vaccinations some scientists mentioned that FULL protein length of Spike protein was dangerous
9:16 IMPLICATION: Antibody Dependent Enhancement (29) or ADE could occur with use of full length of Spike protein
10:27: AUTHORS’ RECOMMENDATION: Not to use full length of spike protein but only the Receptor Binding Domain or RBD portion for vaccines
10:41 Explanation: RBD
11:29: TAKE AWAY Vaccine Safety This shows how Vaccines are still uncharacterized on what they might be doing at the molecular level once injected in us.
11:52 Spike protein also uncharacterized post-infection (but learning lots now).
Related Research to understanding study:
- SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro (30)
- BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation (31)
- V(D)J recombination (32)
- A simplified model for NHEJ and HR. When a DNA double-strand break (DSB) occurs during G1, it is repaired via NHEJ (IMAGES from Publication) (33)
- The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells (34)
- Other Interesting studies regarding writing foreign RNA into the genetic DNA code (35) (36) (37)
Posts on C19 Vaccines
- 89.7% cases occurred among the fully vaccinated
- Dr Janci Lindsay, Ph.D. (Molecular Biologist & Toxicologist) asks CDC & Rabbinical Court to Halt Rollout (Infertility & Mutant Variant concerns)
- [RANT] Pfizer / FDA – Court Released Docs [1st Batch]
- Wow very Interesting Vaccine Batch Report (1 in 200 Harmful Batches – by Design?)
- Spike Protein Goes to Nucleus and Impairs DNA Repair
- Former Pfizer Staff Speak Out
- Six months safety and efficacy of Pfizer
- J&J Employees “Do Not Trust the Media with Anything they Say”
- BMJ: Unclean Data in Vaccine Trials (Pfizer & FDA should be investigated & Rollout Halted)
- If you are Forced to Get the Jab…
- [RANT] People are still dying & hospitalized even after being ‘fully vaccinated’ (UK, Israel)
- Differences between the Vaccines
- Children Extremely Low-Risk & Unlikely To Spread (COVID-19 Studies)
- What is SARS-CoV-2, COVID-19, & Biology 101 to understand the new mRNA vaccines
- The Best PRO & CON Video You’ll EVER see about Vaccines (Opposing Views)
Posts on C19 Vaccine Damage
- Athletes who “suddenly” died or collapsed since vax rollout
- Aussie Nurses, Paramedics, Health Workers speak out about COVID-19 Vaccine Injuries
- Amputations after COVID/Vax
- UK Covid-19 Vaccine Damage Bill
- Brazilian President tells WHO director “People are Dying” after C19 Shots, pleads not to recommend to Kids
- Eddie Warne – Rare??? Jab Reactions & Covid Truthbombs
- They asked for Unvaccinated COVID Death Stories (Got 258k Unexpected Comments)
- Prof. Levi – C19 Vax – Increase in Cardiac arrests & Heart attacks
- Against Our Will [Europe]
- Against Our Will [Australia & New Zealand]
- Aussie Health Workers on Jab Policies
- Heart Damage: mRNA Vaccines (Pfizer/Moderna)
- Health Insights from the first year of COVID-19 in Australia
- It is not “Safe” for everyone
- COVID Vaccine Victims Silenced
- [RANT] I’m heartbroken and helpless and concerned and need to share
Australian C19 References/Research
- Heart Damage: mRNA Vaccines (Pfizer/Moderna)
- Verifiable References for Aussies
- Health Insights from the first year of COVID-19 in Australia
- Cannot prevent disease or transmission, and worsened outcomes for vaccinated against Delta?
- Fair Work Commission on COVID-19
- Vaccine Boosters?
- Preventing Severe Outcomes with Early Treatment vs Government-Policy-Controlled Health Advice
- Informed consent should include this warning prominently & individually explained (ADE)
- It is not “Safe” for everyone
- Infection Fatality Rate of <0.1% for those aged under 70
- LAWS against Mandating Vaccines
- “Experts” Silenced by Policy
- Provisional & Still in Ongoing Clinical Trial
- COVID-19 Vaccines are Experimental
|01↩||SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro – Pubmed|
|02↩||[Rant] I’m heartbroken and helpless and concerned and need to share|
|03↩||C-19 Vaccines [Videos] Doctors & Nurses|
|04↩||Aussie Health Workers On Jab Policies|
|05↩||Verifiable References For Aussies|
|06↩||COVID Vaccine Victims Silenced|
|07↩||Against Our Will|
|08↩||Against Our Will [Europe]|
|09↩||Jiang, H.; Mei, Y.-F. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses 2021, 13, 2056. https://doi.org/10.3390/v13102056|
|10↩||DrBeen – Spike Protein Goes to Nucleus and Impairs DNA Repair (In-Vitro Study) – YouTube|
|11↩||DrBeen -Spike Protein Goes to Nucleus and Impairs DNA Repair (In-Vitro Study) – Odysee|
|12↩||Covid Vaccine Injuries|
|13↩||An unmentioned side-effect of Covid vaccines?|
|15↩||Lies And Damn Lies About Breast Cancer Awareness And Cancer Charities – cancerwisdom.net|
|18↩||She quit Big Pharma to help cancer patients heal naturally|
|21↩||Covid Vaccines and Cancer – Swiss Policy Research|
|22↩||Clinical pathologist Dr. Ryan Cole described a significant increase in certain types of cancer (e.g. endometrial cancer) since the beginning of the covid mass vaccination campaign|
|23↩||CAUSE OF DEATH AFTER COVID-19 VACCINATION Press Conference – German pathologists|
|27↩||Dr. Mikolaj Raszek – Spike protein inside nucleus enhancing DNA damage? – COVID-19 mRNA vaccines – YouTube|
|28↩||Dr. Mikolaj Raszek Credentials: https://merogenomics.ca/en/about/|
|29↩||Informed Consent Should Include This Warning Prominently & Individually Explained (ADE)|
|30↩||Jiang H, Mei Y-F. SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro. Viruses. 2021; 13(10):2056. https://doi.org/10.3390/v13102056|
|31↩||BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation, Cell Reports, Volume 18, Issue 2, 2017, Pages 520-532, ISSN 2211-1247, https://doi.org/10.1016/j.celrep.2016.12.042. Mayu Isono, Atsuko Niimi, Takahiro Oike, Yoshihiko Hagiwara, Hiro Sato, Ryota Sekine, Yukari Yoshida, Shin-Ya Isobe, Chikashi Obuse, Ryotaro Nishi, Elena Petricci, Shinichiro Nakada, Takashi Nakano, Atsushi Shibata|
|32↩||V(D)J recombination is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation. It results in the highly diverse repertoire of antibodies/immunoglobulins and T cell receptors (TCRs) found in B cells and T cells, respectively. The process is a defining feature of the adaptive immune system. V(D)J recombination in mammals occurs in the primary lymphoid organs (bone marrow for B cells and thymus for T cells) and in a nearly random fashion rearranges variable (V), joining (J), and in some cases, diversity (D) gene segments. The process ultimately results in novel amino acid sequences in the antigen-binding regions of immunoglobulins and TCRs that allow for the recognition of antigens from nearly all pathogens including bacteria, viruses, parasites, and worms as well as “altered self cells” as seen in cancer. The recognition can also be allergic in nature (e.g. to pollen or other allergens) or may match host tissues and lead to autoimmunity.|
|33↩||A simplified model for NHEJ and HR. When a DNA double-strand break (DSB) occurs during G1, it is repaired via NHEJ (IMAGES from Publication)|
|34↩||De Lorenzo, Silvana & Patel, Anand & Hurley, Rachel & Kaufmann, Scott. (2013). The Elephant and the Blind Men: Making Sense of PARP Inhibitors in Homologous Recombination Deficient Tumor Cells. Frontiers in oncology. 3. 228. 10.3389/fonc.2013.00228.|
|35↩||Scientists Find Cancer Drivers Hiding in a New Place|
|36↩||Human cells can write foreign RNA into genetic DNA code|
|37↩||Polθ reverse transcribes RNA and promotes RNA-templated DNA repair – Genome-embedded ribonucleotides arrest replicative DNA polymerases (Pols) and cause DNA breaks. — Xiaojiang S. Chen,Richard T. Pomerantz|