mRNA Vaccines cause Immune Suppression (Paper – Jan 2022)

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Paper gives a plausible reason as to why we are seeing so many people having a sudden reoccurring or worsening of past or existing ailments (including cancer).

It goes through scientific literature to summarize that:

  1. the antibodies fade within 3-10 weeks
  2. they don’t work very well against variants
  3. they don’t prevent the spread
  4. that the claim of reducing symptom severity is also in doubt due to fully-vaccinated patients dying and ending up in hospital
  5. they invoke a different immune response than natural infection
  6. they predict their biological impacts are not only causing harm but will be much worse after boosters are introduced, as referenced by countries whom already have introduced a 3rd or 4th dose.

Preprint downloads: ResearchGate | DOI | Authorea | Cloudfront (PDF-Preprint)

Update 25 April 2022:

Finally been peer-reviewed & published – updated, revised version here: (01)

Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs (02)


The mRNA SARS-CoV-2 vaccines were brought to market in response to the widely perceived public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease had no precedent, but desperate times seemed to call for desperate measures.

The mRNA vaccines utilize genetically modified mRNA encoding spike proteins. These alterations hide the mRNA from cellular defenses, promote a longer biological half-life for the proteins, and provoke higher overall spike protein production. However, both experimental and observational evidence reveals a very different immune response to the vaccines compared to the response to infection with SARS-CoV-2. As we will show, the genetic modifications introduced by the vaccine are likely the source of these differential responses.

In this paper, we present the evidence that vaccination, unlike natural infection, induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. We explain the mechanism by which immune cells release into the circulation large quantities of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance.

These disturbances are shown to have a potentially direct causal link to:

  • neurodegenerative disease
  • myocarditis
  • immune thrombocytopenia
  • Bell’s palsy
  • liver disease
  • impaired adaptive immunity
  • increased tumorigenesis
  • and DNA damage.

We show evidence from adverse event reports in the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines excludes them as positive contributors to public health, even in the context of the Covid-19 pandemic.    

My Notes / Take-Homes / Comments

  • Vaccination with an mRNA vaccine initiates a set of biological events that are not only different from that induced by vaccination but are in several ways demonstrably counterproductive to both short- and long-term immune competence and normal cellular function.
  • These vaccinations have now been shown to downregulate critical pathways related to cancer surveillance, infection control, and cellular homeostasis.
  • They introduce into the body highly modified genetic material.
  • Remarkable difference between the characteristics of the immune response to an infection with SARS-CoV-2 as compared with the immune response to an mRNA vaccine against COVID-19. (03) Differential gene expression analysis of peripheral dendritic cells revealed a dramatic upregulation of both type I and type II interferons (IFNs) in COVID-19 patients, but not in vaccinees. One remarkable observation they made was that there was an expansion of circulating hematopoietic stem and progenitor cells (HSPCs) in COVID-19 patients, but this expansion was notably absent following vaccination. A striking expansion in circulating plasmablasts observed in COVID-19 patients was also not seen in the vaccinees. All of these observations are consistent with the idea that the vaccines actively suppress type I IFN signaling.
  • Since long-term pre-clinical and Phase I safety trials were combined with Phase II trials
  • Then phase II and III trials were combined
  • And since even those were terminated early and placebo arms given the injections
  • We look to the pharmacosurveillance system and published reports for safety signals.

Wait… what?


  • It is now clear that the antibodies induced by the vaccines fade in as little as 3 to 10 weeks after the second dose. (04)
  • The Lancet 2021, 398(10298), 385-387

Wait… what? So are we going to get to that 3-weekly Jab Target or Daily Pill or some other “Only a dangerous, ineffective Jab is the way out of this”?

Western Australian Premier Mark McGowan – Jan 20, 2022 – “So far, the science shows that people with only two doses of a COVID vaccine have only a 4 per cent protection against being infected by the Omicron variant. With a third dose it can provide a 64 per cent protection against infection.” – Yep, Australian Politicians have taken the Kool-Aid and doing their part to awaken humanity every time they open their mouths.

Kind of mad at this one – didn’t you promise to protect “those who did the right thing” from severe illness, overburdening hospitals, and death?

Wasn’t there some kind of “safe and effective” song and dance going on over and over and over and over and over – everywhere you look? Oh, your lips are moving. Thanks also for drinking the Kool-Aid and doing your evil-part to awaken humanity: Dr Kerry Chant, NSW Chief Health Officer.

So even though Israel’s 4 x Pfizer doses isn’t helping with Omicron at all, apparently that fact gets disregarded when it comes to trying to enforce the Australian public to believe their bullshit. Boost more, more boosters, urgent boosters. Just keep your stockholders happy and don’t worry about all the dead and injured bodies lying around the place. (05)

Embrace the boosters? That’s your solution? Pretty clear from day one that the jabs don’t protect anyone and have been harming people which you’ve covered-up to the general public, thanks to the censorship and your blatant lies. The only people buying into your fraudulent science is those who you scared the shit out of when you paid others to create or “Parrot” your fraudulent science. Sigh. (06) (07) (08) (09) (10)

Pfizer CEO recently said 2 shots won’t cut it, to get a 3rd, but also that they were “creating a new vaccine” for the variants. (11) (12) (13) (14)

And announced last year they were creating antivirals because vaccines weren’t enough. (15) 

Which has just been approved for provisional use by the TGA (16) (17) (18), even though we already had working treatments (Prednisolone, Ivermectin, HCQ, Zinc, Vitamin D, Vitamin C, Aspirin, Asthma inhalers and by July last year when I was researching, there was already 100’s of things known to help, (19) there’s probably thousands of things now – things we already had access to!) (20) (21) – of which, the ones that particularly helped in conjunction with Zinc was HCQ & Ivermectin – both banned & dismissed by the TGA (22) (23) (24) (25) (26) (27) (28) and condemned as dangerous or ineffective and censored by the media – well those things helped everyone I know, lucky we don’t listen to snake-oil salesmen with an agenda. (29) Yeah, TGA has gone rogue – or perhaps they were always corrupt as their business model is designed that way (they make money from the drugs & trials they approve). There are conflict$ of interest scattered all the way through our parliament and health authorities (30) (31) (32) (33) (34) – and all those under the international arm of this pandemic/reset (35) (36) (37), and all media has been recruited to keep people in fear and away from solutions – basically turned to the dark side for the great reset and other nefarious agendas, and the fact-checkers – a very powerful and effective weapon indeed (kept me in a loop for months!) – are just a front for pharmaceutical or political marketing). Yeah they thought of everything. (38) (39) (40)

And Pfizer buys a Pharmaceutical company that is developing drugs that target cardiovascular, blood cancer, gastroenterology, and dermatology concerns – and the world isn’t enraged (did you all buy shares or something?)

Just wow – how convenient to acquire a company to be able to prescribe the “drugs” to those with all the damage caused by your vaccine! (41) (42) (43) (44) (45) (46) Come on, it’s pretty damn dodgy – I don’t care if you call me a conspiracy theorist if you can’t see this – if you maim people and are immune from any liability, but then profit from the treatment given to people you’ve maimed, you are a criminal. I’m so sick of pharmaceutical companies, the entire sick-care “health” drug cartel, and global corporations getting away with lying, injuring and murdering whilst somehow turning themselves an even higher profit, whilst keeping your reputation with the public as some kind of heroes in this, *PUKE* you are dirty, disgusting, psychopaths. (47) (48) (49) (50)

Hmm, makes me wonder if anyone’s looked into whether these criminals profit from breast cancer treatment, Alzheimer’s or from any of the 80+ pages of various injuries or worsening illnesses reported or observed? Maybe it’s something we can check by searching the app that’s distributed to our medical teams and health software for COVID-19 treatment and management (51) – but it doesn’t include everything they don’t count as COVID-19 or Vaccine related, or maybe we can scroll through the list of recent TGA-Approved Treatments? (52) But that’s for another day, I’d rather leave that up to a researcher to investigate and bring up in future lawsuits or journal publications. The truth might make me really angry.


It has also become apparent that rapidly emerging variants such as the Delta and now the Omicron strain are showing resistance to the antibodies induced by the vaccines, through mutations in the spike protein.


In this paper we call attention to three very important aspects of the safety profile of these vaccinations.

First is the extensively documented subversion of innate immunity, primarily via suppression of IFN-α and its associated signaling cascade. This suppression will have a wide range of consequences, not the least of which include the reactivation of latent viral infections and the reduced ability to effectively combat future infections.

Second is the dysregulation of the system for both preventing and detecting genetically driven malignant transformation within cells and the consequent potential for vaccination to promote those transformations.

Third, mRNA vaccination potentially disrupts intracellular communication carried out by exosomes, and induces cells taking up spike mRNA to produce high levels of spike-carrying exosomes, with potentially serious inflammatory consequences.

Should any of these potentials be fully realized, the impact on billions of people around the world could be enormous and could contribute to both the short-term and long-term disease burden our health care system faces.


Penny... on Health
Penny... on Health

Truth-seeker, ever-questioning, ever-learning, ever-researching, ever delving further and deeper, ever trying to 'figure it out'. This site is a legacy of sorts, a place to collect thoughts, notes, book summaries, & random points of interests.

DISCLAIMER: The information on this website is not medical science or medical advice. I do not have any medical training aside from my own research and interest in this area. The information I publish is not intended to diagnose, treat, cure or prevent any disease, disorder, pain, injury, deformity, or physical or mental condition. I just report my own results, understanding & research.