Journey

Hey everybody, we are here to talk about Ivermectin and colon cancer. Let’s get into it. Alright, so Ivermectin, you may have heard about this in the news lately. We are not very specifically not talking about anything regarding a recent “pandemic that should not be named”, but I do think this medication has gotten a bad rap and so I want to unpack some research that’s been going on between Ivermectin and colon cancer. That’s what we are here to do.

Today, what we are going to talk about is what is Ivermectin, the history of it as a medication. It is more recent uses in cancer. Then just lay out a couple of key questions for you to ask your doctor if you are interested in moving forward with Ivermectin in your plan. I really want to equip you with a couple of things to get you started.

Let’s start with what is Ivermectin. Ivermectin was first discovered in 1970 by two researchers. One named Satoshi Ōmura (大村 智) and another William C. Campbell. ^{(02) Satoshi Ōmura https://en.wikipedia.org/wiki/Satoshi_%C5%8Cmura (03) William C. Campbell https://en.wikipedia.org/wiki/William_C.Campbell(scientist)}

It was an unusual bacteria that Satoshi Ōmura found near a golf course in Japan. He sent it off to William Campbell who did some testing with it and discovered some really interesting things. It was very, very effective in treating a wide range of parasites. ^{(04) Professor Satoshi Ōmura http://satoshi-omura.info/}

It actually won the Nobel Prize in 2015 as what was called a wonder drug or parasitic diseases in both veterinary and human environments, and really incredible discovery that has had a lot of powerful impact in people’s lives. ^{(05) Satoshi Ōmura – Facts. NobelPrize.org. Nobel Prize Outreach AB 2023. https://www.nobelprize.org/prizes/medicine/2015/omura/facts/ “Nobel Prize for their role in the discovery of avermectins and ivermectin”}

Again, there has been some controversial uses suggested in COVID-19 cases specifically, not even going to touch out with a 30 foot pole. (I will ~ Penny) We are just talking about Ivermectin as a medication and its effect on colon cancer.

Let’s take a look at Ivermectin’s uses in cancer. So colorectal cancer is the third most common cancer worldwide today. Ivermectin has been shown to possess different anti-inflammation, antiviral, and anti-tumor properties.

Now a study out of Henan University in China evaluated the application of Ivermectin on pulling cancer proliferation specifically. That’s the study I want to look at. ^{(06) Infection and Immunity Institute and Translational Medical Center of Huaihe Hospital, Henan University, Kaifeng, China. (07) Zhou S, Wu H, Ning W, Wu X, Xu X, Ma Y, Li X, Hu J, Wang C and Wang J (2021) Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth. Front. Pharmacol. 12:717529. doi: 10.3389/fphar.2021.717529}

1. So the results were that Ivermectin inhibited the proliferation of colon cancer cells by arresting the tumor cell cycle.
   • So getting the tumor cell cycle on a what we call a healthy course where it dies out.
   • That’s one major thing in most cancer cells is their death switch is turned off so they don’t ever have something that communicates with them to die off, and so as they multiply, the problem gets worse rather aggressively, and so Ivermectin was shown to arrest that tumor cell cycle.
2. It also changed the morphology, which is really like the shape and behavior of the cancer cells.
   • So it specifically changed how the cancer cells were structured and made them more weak from a structure standpoint.
3. Finally, Ivermectin induced apoptosis.
   • That’s the program cell death cycle.
   • It induced apoptosis in colon cancer cells by doing a few things:
     • It increased caspase activity, which is a hormone that communicates with cells to move into apoptosis
     • Affecting the expression of apoptosis related proteins that had a similar effect.

So really effective medication to induce that apoptosis cycle from a few different angles.

Alright, so this is this is cutting edge information. This research is just coming out in the last few months. So there’s a lot to figure out still, but it is intriguing, and when you’re in the midst of a cancer fight. Cutting edge can be something very worth talking with your doctor about as new things are discovered in the medical realm, and so I want to leave you with just a few suggested questions to ask your doctor if anything that I’ve said here is intriguing to you in your situation.

So here are the three questions.

1. Have you, my doctor, have you reviewed the research regarding colon cancer and Ivermectin?
   • Hopefully that ones self-explanatory – you want to understand when you ask them the next questions, have they actually looked into it or is there a gut response happening here, particularly because again, Ivermectin has a complicated social stigma right now.
2. What are your thoughts on adding Ivermectin to my cancer treatment plan?
   • Okay, so assuming they have researched. If they haven’t researched, ask them to research, so that you can ask the next question.
3. What dose and frequency would you recommend and why?
   • So again, as this research is happening, doctors are trying different doses to see what effects they can have.

Rachel actually just started Ivermectin as a part of her treatment plan based on our conversations with her doctor up in Seattle, and we have a specific dose that we are trying, but we’re also seeing how she tolerates it and how it’s going and may make adjustments as we need to.

So this is very new science that we are keeping an eye on ourselves because we are in the colon cancer world, and it’s very important to us, and we wanted to share these things with you as we are learning together.

If you have any questions or specific thoughts, maybe you have talked with your doctor about this. Maybe they have additional information to look into. We would love to hear from you and continue to broaden our overall knowledge base together, but, with that, I have nothing else to share on Ivermectin at this moment. So we will talk to you soon.